Assay Detail
Functional
CHEMBL675197
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration of compound required against human Dopamine D4.2 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.32 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57176 | — | — | 1 | 8.72 |
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.66 |
| CHEMBL56118 | — | — | 1 | 8.25 |
| CHEMBL60815 | — | — | 1 | 8.17 |
| CHEMBL7927 | FAUC 113 | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57176 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL240773 | QUINPIROLE | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL56118 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL60815 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL7927 | FAUC 113 | EC50 | = | 16.0 | nM | 7.80 |