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Assay Detail

CHEMBL675215

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro ability to displace [3H]spiperone from human cloned Dopamine receptor D3 stably expressed in CHO cells.
20
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(3) dopamine receptor (CHEMBL234)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding.
Lehmann T, Hübner H, Gmeiner P.
Bioorg Med Chem Lett (2001) 11 : 2863 -2866
PubMed 11597417 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 6.26 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL316983 2 8.22
CHEMBL301559 2 8.10
CHEMBL95618 1 6.48
CHEMBL95230 1 6.38
CHEMBL96958 1 6.37
CHEMBL97319 1 6.29
CHEMBL318924 1 6.25
CHEMBL440143 1 6.23
CHEMBL97283 1 6.12
CHEMBL98072 1 6.11
CHEMBL323557 1 5.89
CHEMBL98071 1 5.85
CHEMBL97436 1 5.75
CHEMBL97750 1 5.68
CHEMBL98563 1 5.44
CHEMBL99291 1 5.13
CHEMBL97348 1 5.07
CHEMBL96998 1 5.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL316983 Ki = 6.0 nM 8.22
CHEMBL301559 Ki = 8.0 nM 8.10
CHEMBL301559 Ki = 9.0 nM 8.05
CHEMBL316983 Ki = 150.0 nM 6.82
CHEMBL95618 Ki = 330.0 nM 6.48
CHEMBL95230 Ki = 420.0 nM 6.38
CHEMBL96958 Ki = 430.0 nM 6.37
CHEMBL97319 Ki = 510.0 nM 6.29
CHEMBL318924 Ki = 560.0 nM 6.25
CHEMBL440143 Ki = 590.0 nM 6.23
CHEMBL97283 Ki = 750.0 nM 6.12
CHEMBL98072 Ki = 770.0 nM 6.11
CHEMBL323557 Ki = 1300.0 nM 5.89
CHEMBL98071 Ki = 1400.0 nM 5.85
CHEMBL97436 Ki = 1800.0 nM 5.75
CHEMBL97750 Ki = 2100.0 nM 5.68
CHEMBL98563 Ki = 3600.0 nM 5.44
CHEMBL99291 Ki = 7400.0 nM 5.13
CHEMBL97348 Ki = 8600.0 nM 5.07
CHEMBL96998 Ki = 9700.0 nM 5.01