Assay Detail
Binding
CHEMBL675218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity is the ability to displace [3H]spiperone from human Dopamine receptor D3 expressed in CHO-K1 cells.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and dopaminergic activity of pyridine analogs of 5-hydroxy-2-(di-n-propylamino)tetralin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.96 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273273 | 5-OH-DPAT | — | 1 | 9.18 |
| CHEMBL110888 | — | — | 1 | 9.06 |
| CHEMBL105977 | — | — | 1 | 8.30 |
| CHEMBL105509 | — | — | 1 | 6.80 |
| CHEMBL106047 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273273 | 5-OH-DPAT | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL110888 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL105977 | — | Ki | = | 4.97 | nM | 8.30 |
| CHEMBL105509 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL106047 | — | Ki | = | 366.0 | nM | 6.44 |