Assay Detail
Binding
CHEMBL675240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) tagged HB-EGF stimulated by 12-O-tetradecanoylphorbol 13-acetate(TPA).
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 9 (CHEMBL5982) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New type of metalloproteinase inhibitor: design and synthesis of new phosphonamide-based hydroxamic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.16 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL353536 | — | — | 1 | 7.16 |
| CHEMBL170315 | — | — | 1 | 7.16 |
| CHEMBL173027 | — | — | 1 | 6.75 |
| CHEMBL171962 | — | — | 1 | 6.72 |
| CHEMBL366478 | — | — | 1 | 6.64 |
| CHEMBL355797 | — | — | 1 | 6.58 |
| CHEMBL172885 | — | — | 1 | 6.52 |
| CHEMBL172548 | — | — | 1 | 6.43 |
| CHEMBL173235 | — | — | 1 | 6.37 |
| CHEMBL368857 | — | — | 1 | 6.29 |
| CHEMBL173316 | — | — | 1 | 6.28 |
| CHEMBL177072 | — | — | 1 | 6.25 |
| CHEMBL436049 | — | — | 1 | 6.18 |
| CHEMBL173686 | — | — | 1 | 6.18 |
| CHEMBL175164 | — | — | 1 | 6.16 |
| CHEMBL172249 | — | — | 1 | 6.10 |
| CHEMBL368205 | — | — | 1 | 6.09 |
| CHEMBL172415 | — | — | 1 | 6.08 |
| CHEMBL367710 | — | — | 1 | 6.05 |
| CHEMBL172722 | — | — | 1 | 6.04 |
| CHEMBL173326 | — | — | 1 | 5.97 |
| CHEMBL171292 | — | — | 1 | 5.94 |
| CHEMBL173846 | — | — | 1 | 5.87 |
| CHEMBL170429 | — | — | 1 | 5.80 |
| CHEMBL425316 | — | — | 1 | 5.78 |
| CHEMBL172886 | — | — | 1 | 5.72 |
| CHEMBL539171 | — | — | 1 | 5.71 |
| CHEMBL173744 | — | — | 1 | 5.65 |
| CHEMBL171986 | — | — | 1 | 5.58 |
| CHEMBL174315 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL353536 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL170315 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL173027 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL171962 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL366478 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL355797 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL172885 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL172548 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL173235 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL368857 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL173316 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL177072 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL436049 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL173686 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL175164 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL172249 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL368205 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL172415 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL367710 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL172722 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL173326 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL171292 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL173846 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL170429 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL425316 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL172886 | — | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL539171 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL173744 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL171986 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL174315 | — | IC50 | = | 3110.0 | nM | 5.51 |
| CHEMBL173754 | — | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL418655 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL174014 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL433981 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL172181 | — | IC50 | > | 10000.0 | nM | - |