Assay Detail
Binding
CHEMBL675248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of heparin-binding HB-EGF shedding
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Azasugar-based MMP/ADAM inhibitors as antipsoriatic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.43 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43087 | — | — | 1 | 7.55 |
| CHEMBL58577 | — | — | 1 | 7.08 |
| CHEMBL56837 | — | — | 1 | 6.47 |
| CHEMBL61193 | — | — | 1 | 6.46 |
| CHEMBL57644 | — | — | 1 | 6.35 |
| CHEMBL60536 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43087 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL58577 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL56837 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL61193 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL57644 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL60536 | — | IC50 | = | 21000.0 | nM | 4.68 |