Assay Detail
Binding
CHEMBL675302
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The compound was evaluated for its binding affinity towards human neutrophil elastase (HNE)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.73 | 10.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543416 | — | — | 1 | 10.85 |
| CHEMBL542949 | — | — | 1 | 9.80 |
| CHEMBL2368616 | — | — | 1 | 9.51 |
| CHEMBL554013 | — | — | 1 | 8.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543416 | — | Ki | = | 0.014 | nM | 10.85 |
| CHEMBL542949 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL2368616 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL554013 | — | Ki | = | 1.73 | nM | 8.76 |