Assay Detail
Binding
CHEMBL675303
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The compound was tested in vitro for ability to inhibit human leukocyte elastase activity
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Non-peptidic inhibitors of human leukocyte elastase. 1. The design and synthesis of pyridone-containing inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.75 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105233 | — | — | 1 | 7.92 |
| CHEMBL321296 | — | — | 1 | 7.50 |
| CHEMBL104303 | — | — | 1 | 7.47 |
| CHEMBL75936 | — | — | 1 | 7.44 |
| CHEMBL107291 | — | — | 1 | 7.40 |
| CHEMBL107191 | — | — | 1 | 7.38 |
| CHEMBL104289 | — | — | 1 | 7.33 |
| CHEMBL107966 | — | — | 1 | 7.32 |
| CHEMBL104032 | — | — | 1 | 7.29 |
| CHEMBL106793 | — | — | 1 | 7.16 |
| CHEMBL104557 | — | — | 1 | 7.15 |
| CHEMBL104396 | — | — | 1 | 7.06 |
| CHEMBL106066 | — | — | 1 | 7.06 |
| CHEMBL106888 | — | — | 1 | 7.05 |
| CHEMBL13684 | — | — | 1 | 6.55 |
| CHEMBL105124 | — | — | 1 | 6.50 |
| CHEMBL104050 | — | — | 1 | 6.46 |
| CHEMBL105067 | — | — | 1 | 6.30 |
| CHEMBL322177 | — | — | 1 | 5.58 |
| CHEMBL14223 | — | — | 1 | 5.57 |
| CHEMBL25490 | — | — | 1 | 5.55 |
| CHEMBL107329 | — | — | 1 | 5.47 |
| CHEMBL104250 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105233 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL321296 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL104303 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL75936 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL107291 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL107191 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL104289 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL107966 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL104032 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL106793 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL104557 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL104396 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL106066 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL106888 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL13684 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL105124 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL104050 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL105067 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL322177 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL14223 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL25490 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL107329 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL104250 | — | Ki | = | 15000.0 | nM | 4.82 |