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Assay Detail

CHEMBL675326

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Functional
Inhibitory activity against EMT6 murine cell line
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type EMT6
Confidence 1 — Organism
Curated By Intermediate

Target

EMT6 (CHEMBL614294)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.
Hay MP, Anderson RF, Ferry DM, Wilson WR, Denny WA.
J Med Chem (2003) 46 : 5533 -5545
PubMed 14640560 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.35 6.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL37705 1 6.43
CHEMBL275497 1 5.97
CHEMBL155391 1 5.94
CHEMBL151191 1 5.89
CHEMBL151008 1 5.79
CHEMBL346169 1 5.37
CHEMBL345280 1 4.75
CHEMBL152837 1 4.71
CHEMBL278726 1 4.41
CHEMBL23612 1 4.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL37705 IC50 = 370.0 nM 6.43
CHEMBL275497 IC50 = 1060.0 nM 5.97
CHEMBL155391 IC50 = 1160.0 nM 5.94
CHEMBL151191 IC50 = 1300.0 nM 5.89
CHEMBL151008 IC50 = 1630.0 nM 5.79
CHEMBL346169 IC50 = 4300.0 nM 5.37
CHEMBL345280 IC50 = 18000.0 nM 4.75
CHEMBL152837 IC50 = 19600.0 nM 4.71
CHEMBL278726 IC50 = 39000.0 nM 4.41
CHEMBL23612 IC50 = 54000.0 nM 4.27