Assay Detail
Binding
CHEMBL675569
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Inhibition of human endothelial Nitric Oxide Synthase expressed in Sf-21 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.04 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75304 | — | — | 1 | 6.64 |
| CHEMBL74919 | — | — | 1 | 6.62 |
| CHEMBL75484 | — | — | 1 | 6.50 |
| CHEMBL72316 | — | — | 1 | 6.44 |
| CHEMBL76342 | — | — | 1 | 6.36 |
| CHEMBL75428 | — | — | 1 | 6.29 |
| CHEMBL75905 | — | — | 1 | 6.28 |
| CHEMBL75496 | — | — | 1 | 6.24 |
| CHEMBL260277 | — | — | 1 | 5.82 |
| CHEMBL308310 | — | — | 1 | 5.68 |
| CHEMBL74679 | — | — | 1 | 5.13 |
| CHEMBL75794 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75304 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL74919 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL75484 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL72316 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL76342 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL75428 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL75905 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL75496 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL260277 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL308310 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL74679 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL75794 | — | IC50 | = | 31000.0 | nM | 4.51 |