Assay Detail
Binding
CHEMBL675646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit [3H]mazindol binding to cloned human dopamine (DA) transporter
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of some known and putative duloxetine metabolites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.38 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119605 | — | — | 1 | 5.55 |
| CHEMBL2029053 | — | — | 1 | 5.46 |
| CHEMBL326713 | — | — | 2 | 5.14 |
| CHEMBL2029054 | — | — | 1 | - |
| CHEMBL420142 | — | — | 1 | - |
| CHEMBL2029052 | — | — | 1 | - |
| CHEMBL2029055 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119605 | — | Ki | = | 2814.0 | nM | 5.55 |
| CHEMBL2029053 | — | Ki | = | 3509.0 | nM | 5.46 |
| CHEMBL326713 | — | Ki | = | 7275.0 | nM | 5.14 |
| CHEMBL2029054 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL420142 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2029052 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2029055 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL326713 | — | Ki | > | 10000.0 | nM | - |