Assay Detail
Binding
CHEMBL675661
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Binding affinity for sigma-1 site over dopamine (D2) receptor in rat using [3H]spiperone as radioligand
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.40 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL554628 | — | — | 1 | 7.26 |
| CHEMBL545678 | — | — | 1 | 6.71 |
| CHEMBL558028 | — | — | 1 | 6.67 |
| CHEMBL541284 | — | — | 1 | 6.46 |
| CHEMBL542630 | — | — | 1 | 6.33 |
| CHEMBL555580 | — | — | 1 | 6.30 |
| CHEMBL537464 | — | — | 1 | 6.00 |
| CHEMBL544516 | — | — | 1 | 5.96 |
| CHEMBL540013 | — | — | 1 | 5.92 |
| CHEMBL537989 | — | — | 1 | - |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL554628 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL545678 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL558028 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL541284 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL542630 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL555580 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL537464 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL544516 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL540013 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL537989 | — | Ki | > | 500.0 | nM | - |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | > | 5000.0 | nM | - |