Assay Detail
Binding
CHEMBL675667
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Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D3 expressed on CHO K-1 cells.
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.47 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269004 | — | — | 1 | 9.27 |
| CHEMBL301559 | — | — | 1 | 9.24 |
| CHEMBL336652 | — | — | 1 | 9.18 |
| CHEMBL134571 | — | — | 1 | 9.15 |
| CHEMBL335392 | — | — | 1 | 9.13 |
| CHEMBL135954 | — | — | 1 | 9.12 |
| CHEMBL334472 | — | — | 1 | 9.12 |
| CHEMBL94015 | — | — | 1 | 8.96 |
| CHEMBL135932 | — | — | 1 | 8.85 |
| CHEMBL7806 | — | — | 1 | 8.74 |
| CHEMBL134747 | — | — | 1 | 8.70 |
| CHEMBL109684 | — | — | 1 | 8.47 |
| CHEMBL1303 | ROTIGOTINE | 4.0 | 1 | 8.40 |
| CHEMBL133830 | — | — | 1 | 8.29 |
| CHEMBL305706 | — | — | 1 | 7.24 |
| CHEMBL15146 | — | — | 1 | 7.12 |
| CHEMBL336295 | — | — | 1 | 6.95 |
| CHEMBL135152 | — | — | 1 | 6.87 |
| CHEMBL133938 | — | — | 1 | 6.81 |
| CHEMBL132261 | — | — | 1 | 6.68 |
| CHEMBL135944 | — | — | 1 | 6.58 |
| CHEMBL441092 | — | — | 1 | 6.46 |
| CHEMBL134866 | — | — | 1 | 6.44 |
| CHEMBL135048 | — | — | 1 | 6.39 |
| CHEMBL134759 | — | — | 1 | 6.30 |
| CHEMBL11615 | — | — | 1 | 6.28 |
| CHEMBL131851 | — | — | 1 | 6.22 |
| CHEMBL134326 | — | — | 1 | 6.19 |
| CHEMBL30560 | — | — | 1 | 6.17 |
| CHEMBL134701 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269004 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL301559 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL336652 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL134571 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL335392 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL135954 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL334472 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL94015 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL135932 | — | Ki | = | 1.41 | nM | 8.85 |
| CHEMBL7806 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL134747 | — | Ki | = | 1.98 | nM | 8.70 |
| CHEMBL109684 | — | Ki | = | 3.37 | nM | 8.47 |
| CHEMBL1303 | ROTIGOTINE | Ki | = | 3.99 | nM | 8.40 |
| CHEMBL133830 | — | Ki | = | 5.12 | nM | 8.29 |
| CHEMBL305706 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL15146 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL336295 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL135152 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL133938 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL132261 | — | Ki | = | 211.0 | nM | 6.68 |
| CHEMBL135944 | — | Ki | = | 266.0 | nM | 6.58 |
| CHEMBL441092 | — | Ki | = | 343.0 | nM | 6.46 |
| CHEMBL134866 | — | Ki | = | 361.0 | nM | 6.44 |
| CHEMBL135048 | — | Ki | = | 409.0 | nM | 6.39 |
| CHEMBL134759 | — | Ki | = | 501.0 | nM | 6.30 |
| CHEMBL11615 | — | Ki | = | 529.0 | nM | 6.28 |
| CHEMBL131851 | — | Ki | = | 603.0 | nM | 6.22 |
| CHEMBL134326 | — | Ki | = | 648.0 | nM | 6.19 |
| CHEMBL30560 | — | Ki | = | 683.0 | nM | 6.17 |
| CHEMBL134701 | — | Ki | = | 857.0 | nM | 6.07 |
| CHEMBL335971 | — | Ki | = | 1372.0 | nM | 5.86 |
| CHEMBL422274 | — | Ki | = | 2220.0 | nM | 5.65 |
| CHEMBL336962 | — | Ki | = | 3055.0 | nM | 5.51 |