Assay Detail

CHEMBL675670

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Binding

Binding affinity towards human dopamine receptor D3

ChEMBL ↗

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Target

D(3) dopamine receptor (CHEMBL234) ↗

Open DB target context

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D(3) dopamine receptor (CHEMBL234) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target D(3) dopamine receptor

CHEMBL234

Anchored from Assay target.

Protein identity D(3) dopamine receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

D(3) dopamine receptor (CHEMBL234) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Current and novel approaches to the drug treatment of schizophrenia.

Rowley M, Bristow LJ, Hutson PH.
J Med Chem (2001) 44 : 477 -501
PubMed 11170639 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	6	7.40	8.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL285802	ZOTEPINE	2.0	1	8.19
CHEMBL708	ZIPRASIDONE	4.0	1	8.00
CHEMBL85	RISPERIDONE	4.0	1	7.85
CHEMBL715	OLANZAPINE	4.0	1	7.31
CHEMBL42	CLOZAPINE	4.0	1	6.55
CHEMBL716	QUETIAPINE	4.0	1	6.47

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL285802	ZOTEPINE	Ki	=	6.4	nM	8.19
CHEMBL708	ZIPRASIDONE	Ki	=	10.0	nM	8.00
CHEMBL85	RISPERIDONE	Ki	=	14.0	nM	7.85
CHEMBL715	OLANZAPINE	Ki	=	49.0	nM	7.31
CHEMBL42	CLOZAPINE	Ki	=	280.0	nM	6.55
CHEMBL716	QUETIAPINE	Ki	=	340.0	nM	6.47