Assay Detail
Functional
CHEMBL675688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal effect on the accumulation of [3H]- daunorubicin in mouse mammary carcinoma cell line EMT6/AR 1.0
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | EMT6 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.31 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347194 | — | — | 1 | 7.42 |
| CHEMBL348475 | TARIQUIDAR | 3.0 | 1 | 7.42 |
| CHEMBL156058 | — | — | 1 | 7.35 |
| CHEMBL265750 | — | — | 1 | 7.22 |
| CHEMBL345804 | — | — | 1 | 7.17 |
| CHEMBL155308 | — | — | 1 | 7.17 |
| CHEMBL444075 | — | — | 1 | 7.06 |
| CHEMBL347245 | — | — | 1 | 7.04 |
| CHEMBL347608 | — | — | 1 | 6.85 |
| CHEMBL158175 | — | — | 1 | 6.83 |
| CHEMBL157506 | — | — | 1 | 6.69 |
| CHEMBL155249 | — | — | 1 | 6.66 |
| CHEMBL346124 | — | — | 1 | 6.66 |
| CHEMBL346292 | — | — | 1 | 6.60 |
| CHEMBL347146 | — | — | 1 | 6.53 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.36 |
| CHEMBL155203 | — | — | 1 | 6.17 |
| CHEMBL156869 | — | — | 1 | 6.14 |
| CHEMBL155169 | — | — | 1 | 6.10 |
| CHEMBL348579 | — | — | 1 | 6.07 |
| CHEMBL155055 | — | — | 1 | 6.06 |
| CHEMBL347784 | — | — | 1 | 6.04 |
| CHEMBL157969 | — | — | 1 | 5.96 |
| CHEMBL350253 | — | — | 1 | 5.96 |
| CHEMBL156318 | — | — | 1 | 5.80 |
| CHEMBL157804 | — | — | 1 | 5.77 |
| CHEMBL348559 | — | — | 1 | 5.64 |
| CHEMBL154800 | — | — | 1 | 5.62 |
| CHEMBL154994 | — | — | 1 | 5.57 |
| CHEMBL155285 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347194 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL348475 | TARIQUIDAR | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL156058 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL265750 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL345804 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL155308 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL444075 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL347245 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL347608 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL158175 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL157506 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL155249 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL346124 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL346292 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL347146 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL155203 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL156869 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL155169 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL348579 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL155055 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL347784 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL157969 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL350253 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL156318 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL157804 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL348559 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL154800 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL154994 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL155285 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL156183 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL154732 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL345889 | — | IC50 | = | 6800.0 | nM | 5.17 |