Assay Detail
Functional
CHEMBL675690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against P-glycoprotein (Pgp) using accumulation assay for Pgp expressing EMT6/AR1.0 cells.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.71 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL152651 | — | — | 1 | 7.30 |
| CHEMBL156894 | — | — | 1 | 6.80 |
| CHEMBL154490 | — | — | 1 | 6.41 |
| CHEMBL356478 | — | — | 1 | 6.22 |
| CHEMBL154596 | — | — | 1 | 6.20 |
| CHEMBL152590 | — | — | 1 | 6.10 |
| CHEMBL435437 | — | — | 1 | 6.07 |
| CHEMBL156947 | — | — | 1 | 6.00 |
| CHEMBL154003 | — | — | 1 | 5.99 |
| CHEMBL152157 | — | — | 1 | 5.97 |
| CHEMBL421980 | — | — | 1 | 5.97 |
| CHEMBL264490 | — | — | 1 | 5.96 |
| CHEMBL345316 | — | — | 1 | 5.89 |
| CHEMBL423413 | — | — | 1 | 5.87 |
| CHEMBL433715 | — | — | 1 | 5.80 |
| CHEMBL346486 | — | — | 1 | 5.77 |
| CHEMBL157162 | — | — | 1 | 5.72 |
| CHEMBL152447 | — | — | 1 | 5.70 |
| CHEMBL357996 | — | — | 1 | 5.68 |
| CHEMBL157318 | — | — | 1 | 5.43 |
| CHEMBL356477 | — | — | 1 | 5.38 |
| CHEMBL350775 | BIRICODAR | 2.0 | 1 | 5.30 |
| CHEMBL347672 | — | — | 1 | 5.30 |
| CHEMBL154430 | — | — | 1 | 5.14 |
| CHEMBL357064 | — | — | 1 | 5.10 |
| CHEMBL154004 | — | — | 1 | 5.00 |
| CHEMBL348567 | — | — | 1 | 4.85 |
| CHEMBL152046 | — | — | 1 | 4.40 |
| CHEMBL153452 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL152651 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL156894 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL154490 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL356478 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL154596 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL152590 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL435437 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL156947 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL154003 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL152157 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL421980 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL264490 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL345316 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL423413 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL433715 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL346486 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL157162 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL152447 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL357996 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL157318 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL356477 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL350775 | BIRICODAR | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL347672 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL154430 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL357064 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL154004 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL348567 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL152046 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL153452 | — | IC50 | = | 41000.0 | nM | 4.39 |