Assay Detail
Binding
CHEMBL675818
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Ability to displace [3H]spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK293 cells.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 7.63 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78923 | — | — | 1 | 9.00 |
| CHEMBL61079 | — | — | 1 | 8.92 |
| CHEMBL78933 | — | — | 1 | 8.82 |
| CHEMBL309901 | — | — | 1 | 8.80 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.64 |
| CHEMBL293341 | — | — | 1 | 8.60 |
| CHEMBL80318 | — | — | 1 | 8.51 |
| CHEMBL444309 | — | — | 1 | 8.46 |
| CHEMBL61195 | — | — | 1 | 8.44 |
| CHEMBL80722 | — | — | 1 | 8.33 |
| CHEMBL6416 | — | — | 1 | 8.26 |
| CHEMBL76090 | — | — | 1 | 8.04 |
| CHEMBL77744 | — | — | 1 | 8.00 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.00 |
| CHEMBL25938 | — | — | 1 | 7.96 |
| CHEMBL2112285 | — | — | 1 | 7.92 |
| CHEMBL420954 | — | — | 1 | 7.89 |
| CHEMBL77743 | — | — | 1 | 7.72 |
| CHEMBL312255 | — | — | 1 | 7.70 |
| CHEMBL310819 | — | — | 1 | 7.66 |
| CHEMBL309460 | — | — | 1 | 7.64 |
| CHEMBL310985 | — | — | 1 | 7.64 |
| CHEMBL58296 | — | — | 1 | 7.36 |
| CHEMBL80207 | — | — | 1 | 7.33 |
| CHEMBL79098 | — | — | 1 | 7.28 |
| CHEMBL78287 | — | — | 1 | 7.22 |
| CHEMBL61080 | — | — | 1 | 7.21 |
| CHEMBL77017 | — | — | 1 | 6.96 |
| CHEMBL76355 | — | — | 1 | 6.96 |
| CHEMBL77148 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78923 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL61079 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL78933 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL309901 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL293341 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL80318 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL444309 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL61195 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL80722 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL6416 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL76090 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL77744 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL42 | CLOZAPINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL25938 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL2112285 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL420954 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL77743 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL312255 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL310819 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL309460 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL310985 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL58296 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL80207 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL79098 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL78287 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL61080 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL76355 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL77017 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL77148 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2112284 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL80833 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL77015 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL311832 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL80552 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL80863 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL75691 | — | Ki | > | 3300.0 | nM | - |