Assay Detail
Binding
CHEMBL675857
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro displacement of [3H]spiperone from the recombinant human dopamine receptor D4 expressed in CHO cells
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.53 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62602 | — | — | 1 | 7.96 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.80 |
| CHEMBL2111525 | — | — | 1 | 7.70 |
| CHEMBL64752 | — | — | 1 | 7.41 |
| CHEMBL302186 | — | — | 1 | 7.28 |
| CHEMBL2111527 | — | — | 1 | 6.82 |
| CHEMBL2111528 | — | — | 1 | 6.82 |
| CHEMBL65641 | — | — | 1 | 6.77 |
| CHEMBL64139 | — | — | 1 | 6.77 |
| CHEMBL294780 | — | — | 1 | 6.60 |
| CHEMBL59702 | — | — | 1 | 6.46 |
| CHEMBL64288 | — | — | 1 | 6.43 |
| CHEMBL293645 | — | — | 1 | 6.43 |
| CHEMBL59749 | — | — | 2 | 6.41 |
| CHEMBL293225 | — | — | 1 | 6.41 |
| CHEMBL62624 | — | — | 1 | 6.40 |
| CHEMBL64376 | — | — | 1 | 6.35 |
| CHEMBL2111526 | — | — | 1 | 6.29 |
| CHEMBL62996 | — | — | 1 | 6.24 |
| CHEMBL64325 | — | — | 1 | 6.23 |
| CHEMBL64043 | — | — | 1 | 6.23 |
| CHEMBL64668 | — | — | 1 | 6.19 |
| CHEMBL64696 | — | — | 1 | 6.15 |
| CHEMBL64566 | — | — | 1 | 5.96 |
| CHEMBL62703 | — | — | 1 | 5.84 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | 5.68 |
| CHEMBL62601 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62602 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL42 | CLOZAPINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2111525 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL64752 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL302186 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL2111527 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL2111528 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL65641 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL64139 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL294780 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL59702 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL64288 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL293645 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL59749 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL59749 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL293225 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL62624 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL64376 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL2111526 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL62996 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL64325 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL64043 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL64668 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL64696 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL64566 | — | Ki | = | 1110.0 | nM | 5.96 |
| CHEMBL62703 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL62601 | — | Ki | = | 15500.0 | nM | 4.81 |