Assay Detail
Binding
CHEMBL675959
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Tested for the inhibitory activity against D2H (high-affinity states) receptor in infected HEK 293 cells.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Iodinated 2-aminotetralins and 3-amino-1-benzopyrans: ligands for dopamine D2 and D3 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.89 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263282 | — | — | 1 | 8.44 |
| CHEMBL110239 | — | — | 1 | 8.18 |
| CHEMBL336851 | — | — | 1 | 8.01 |
| CHEMBL133085 | — | — | 1 | 7.97 |
| CHEMBL285755 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263282 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL110239 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL336851 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL133085 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL285755 | — | Ki | = | 142.0 | nM | 6.85 |