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Assay Detail

CHEMBL676079

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against endothelin-converting enzyme
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Endothelin-converting enzyme 1 (CHEMBL2676)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Non-peptidic inhibitors of neutral endopeptidase 24.11 2. Design and pharmacology of orally active phosphonate prodrugs
De Lombaer S, Blanchard L, Berry C, Ghai RD, Trapani AJ
Bioorg Med Chem Lett (1995) 5 : 151 -154
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.96 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL290698 1 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL290698 IC50 = 1100.0 nM 5.96