Assay Detail
Functional
CHEMBL676117
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Stimulation of alkaline phosphatase activity in Ishikawa human endometrial adenocarcinoma cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Ishikawa |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of novel thio-substituted chromanes as high-affinity partial agonists for the estrogen receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 9.10 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 10.40 |
| CHEMBL1628161 | MOXESTROL | 2.0 | 1 | 10.10 |
| CHEMBL554789 | — | — | 1 | 9.30 |
| CHEMBL299942 | — | — | 1 | 9.15 |
| CHEMBL417596 | — | — | 1 | 9.05 |
| CHEMBL52598 | — | — | 1 | 8.74 |
| CHEMBL6318 | IDOXIFENE | 2.0 | 1 | 8.15 |
| CHEMBL301327 | LEVORMELOXIFENE | 2.0 | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81 | RALOXIFENE | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL1628161 | MOXESTROL | EC50 | = | 0.08 | nM | 10.10 |
| CHEMBL554789 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL299942 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL417596 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL52598 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL6318 | IDOXIFENE | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL301327 | LEVORMELOXIFENE | EC50 | = | 13.0 | nM | 7.89 |