Assay Detail
Binding
CHEMBL676139
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Binding affinity towards baculovirus expressed rat dopamine D3 receptors
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.85 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10085 | MAZAPERTINE | 2.0 | 1 | 8.74 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.52 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10085 | MAZAPERTINE | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL42 | CLOZAPINE | Ki | = | 500.0 | nM | 6.30 |