Assay Detail
Binding
CHEMBL676140
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for binding affinity against cloned mammalian Dopamine receptor D3 expressed in CHO cells by, using [3H]spiperone as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships in the 8-amino-6,7,8,9-tetrahydro-3H-benz[e]indole ring system. 1. Effects of substituents in the aromatic system on serotonin and dopamine receptor subtypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.78 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL441256 | — | — | 1 | 7.19 |
| CHEMBL71899 | — | — | 1 | 6.87 |
| CHEMBL302373 | — | — | 1 | 6.81 |
| CHEMBL71319 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL441256 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL71899 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL302373 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL71319 | — | Ki | = | 572.0 | nM | 6.24 |