Assay Detail
Binding
CHEMBL676183
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Binding affinity to dopamine receptor D4 cloned from human, using [3H]- YM09151 as competitive ligand
34
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: mixed dopamine D(2)/D(4) receptor antagonists as potential antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.62 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1202216 | — | — | 1 | 8.52 |
| CHEMBL1202211 | — | — | 1 | 8.52 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.30 |
| CHEMBL1202220 | — | — | 1 | 8.30 |
| CHEMBL1204116 | — | — | 2 | 8.22 |
| CHEMBL1202214 | — | — | 1 | 8.22 |
| CHEMBL2092961 | — | — | 1 | 8.15 |
| CHEMBL1202208 | — | — | 1 | 8.10 |
| CHEMBL1202215 | — | — | 1 | 8.10 |
| CHEMBL1202205 | — | — | 1 | 8.05 |
| CHEMBL1202213 | — | — | 1 | 8.05 |
| CHEMBL1202212 | — | — | 1 | 8.00 |
| CHEMBL1202219 | — | — | 1 | 8.00 |
| CHEMBL1202204 | — | — | 1 | 7.80 |
| CHEMBL1204119 | — | — | 1 | 7.77 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.77 |
| CHEMBL1202223 | — | — | 1 | 7.54 |
| CHEMBL1202222 | — | — | 1 | 7.52 |
| CHEMBL1202210 | — | — | 1 | 7.51 |
| CHEMBL1202217 | — | — | 1 | 7.43 |
| CHEMBL1202202 | — | — | 1 | 7.37 |
| CHEMBL1202206 | — | — | 1 | 7.35 |
| CHEMBL341497 | — | — | 1 | 7.32 |
| CHEMBL1202209 | — | — | 1 | 7.17 |
| CHEMBL1202224 | — | — | 1 | 7.14 |
| CHEMBL1202221 | — | — | 1 | 7.07 |
| CHEMBL1203260 | — | — | 1 | 7.02 |
| CHEMBL125455 | — | — | 1 | 6.88 |
| CHEMBL1202225 | — | — | 1 | 6.79 |
| CHEMBL1203257 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1202216 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1202211 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1202220 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1202214 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1204116 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2092961 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1202215 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1202208 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1204116 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1202213 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1202205 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1202212 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1202219 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1202204 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1204119 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1202223 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1202222 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1202210 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1202217 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1202202 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1202206 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL341497 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1202209 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1202224 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1202221 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1203260 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL125455 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL1202225 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL1203257 | — | IC50 | = | 567.0 | nM | 6.25 |
| CHEMBL22242 | REMOXIPRIDE | IC50 | = | 3872.0 | nM | 5.41 |
| CHEMBL1202207 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1202203 | — | IC50 | > | 10000.0 | nM | - |