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Assay Detail

CHEMBL676184

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro binding affinity at human cloned Dopamine receptor D4.2 by [3H]YM-09151-2 displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(4) dopamine receptor (CHEMBL219)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand.
Perrone R, Berardi F, Colabufo NA, Leopoldo M, Tortorella V.
J Med Chem (1998) 41 : 4903 -4909
PubMed 9822559 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.72 10.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL93403 1 10.24
CHEMBL147483 1 9.00
CHEMBL286725 1 9.00
CHEMBL54 HALOPERIDOL 4.0 1 8.89
CHEMBL357448 1 8.55
CHEMBL26677 1 8.51
CHEMBL356358 1 8.40
CHEMBL144811 1 8.11
CHEMBL42 CLOZAPINE 4.0 1 7.64
CHEMBL2373204 1 7.52
CHEMBL2373210 1 7.52
CHEMBL26929 1 7.22
CHEMBL2373207 1 7.16
CHEMBL2373205 1 6.96
CHEMBL359002 1 6.92
CHEMBL424125 1 6.55
CHEMBL2373208 1 6.33
CHEMBL2373206 1 6.13
CHEMBL2373209 1 6.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL93403 IC50 = 0.057 nM 10.24
CHEMBL147483 IC50 = 1.0 nM 9.00
CHEMBL286725 IC50 = 1.0 nM 9.00
CHEMBL54 HALOPERIDOL IC50 = 1.3 nM 8.89
CHEMBL357448 IC50 = 2.8 nM 8.55
CHEMBL26677 IC50 = 3.1 nM 8.51
CHEMBL356358 IC50 = 4.0 nM 8.40
CHEMBL144811 IC50 = 7.8 nM 8.11
CHEMBL42 CLOZAPINE IC50 = 23.0 nM 7.64
CHEMBL2373204 IC50 = 30.0 nM 7.52
CHEMBL2373210 IC50 = 30.0 nM 7.52
CHEMBL26929 IC50 = 60.0 nM 7.22
CHEMBL2373207 IC50 = 70.0 nM 7.16
CHEMBL2373205 IC50 = 110.0 nM 6.96
CHEMBL359002 IC50 = 120.0 nM 6.92
CHEMBL424125 IC50 = 280.0 nM 6.55
CHEMBL2373208 IC50 = 470.0 nM 6.33
CHEMBL2373206 IC50 = 740.0 nM 6.13
CHEMBL2373209 IC50 = 850.0 nM 6.07