Assay Detail
Binding
CHEMBL676205
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The compound was evaluated in vitro for the inhibition of human leukocyte elastase(HLE)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Enantioselective synthesis and antielastase activity of 1,3,4-trisubstituted and 3,4-disubstituted -lactam antibiotics
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.01 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24983 | — | — | 1 | 7.00 |
| CHEMBL431207 | — | — | 1 | 5.85 |
| CHEMBL84758 | — | — | 1 | 5.80 |
| CHEMBL313683 | — | — | 1 | 4.96 |
| CHEMBL82333 | — | — | 1 | 4.89 |
| CHEMBL314222 | — | — | 1 | 4.75 |
| CHEMBL85693 | — | — | 1 | 4.37 |
| CHEMBL418925 | — | — | 1 | 4.35 |
| CHEMBL313838 | — | — | 1 | 4.12 |
| CHEMBL310133 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24983 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL431207 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL84758 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL313683 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL82333 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL314222 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL85693 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL418925 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL313838 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL310133 | — | IC50 | = | 94000.0 | nM | 4.03 |