Assay Detail
Binding
CHEMBL676288
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Binding affinity which represents concentration giving half-maximal inhibition of [3H]7-OH-DPAT binding to Dopamine receptor D3 in rat tissue homogenate
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Tissue |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.86 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120512 | — | — | 2 | 8.39 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 7.96 |
| CHEMBL333246 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120512 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL59 | DOPAMINE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL333246 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL120512 | — | Ki | = | - | nM | - |