Assay Detail
Binding
CHEMBL676503
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In vitro ability of compound to inhibit binding of [3H]spiperone to human Dopamine receptor D4
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New series of morpholine and 1,4-oxazepane derivatives as dopamine D4 receptor ligands: synthesis and 3D-QSAR model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 7.37 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104035 | — | — | 1 | 8.70 |
| CHEMBL104550 | — | — | 1 | 8.55 |
| CHEMBL105696 | — | — | 1 | 8.54 |
| CHEMBL108122 | — | — | 1 | 8.36 |
| CHEMBL325789 | — | — | 1 | 8.35 |
| CHEMBL104801 | — | — | 1 | 8.31 |
| CHEMBL104041 | — | — | 1 | 8.27 |
| CHEMBL107068 | — | — | 1 | 8.26 |
| CHEMBL105181 | — | — | 1 | 8.15 |
| CHEMBL107691 | — | — | 1 | 8.03 |
| CHEMBL106599 | — | — | 1 | 7.89 |
| CHEMBL421403 | — | — | 1 | 7.89 |
| CHEMBL104873 | — | — | 1 | 7.64 |
| CHEMBL105686 | — | — | 1 | 7.62 |
| CHEMBL106665 | — | — | 1 | 7.54 |
| CHEMBL104089 | — | — | 1 | 7.52 |
| CHEMBL104431 | — | — | 1 | 7.50 |
| CHEMBL105234 | — | — | 1 | 7.50 |
| CHEMBL104485 | — | — | 1 | 7.50 |
| CHEMBL104079 | — | — | 1 | 7.46 |
| CHEMBL104307 | — | — | 1 | 7.40 |
| CHEMBL104216 | — | — | 1 | 7.40 |
| CHEMBL104476 | — | — | 1 | 7.34 |
| CHEMBL321701 | — | — | 1 | 7.28 |
| CHEMBL107019 | — | — | 1 | 7.21 |
| CHEMBL104378 | — | — | 1 | 7.21 |
| CHEMBL322519 | — | — | 1 | 7.16 |
| CHEMBL322175 | — | — | 1 | 7.08 |
| CHEMBL105661 | — | — | 1 | 7.00 |
| CHEMBL2112466 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104035 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL104550 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL105696 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL108122 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL325789 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL104801 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL104041 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL107068 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL105181 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL107691 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL421403 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL106599 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL104873 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL105686 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL106665 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL104089 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL104431 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL105234 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL104485 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL104079 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL104307 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL104216 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL104476 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL321701 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL107019 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL104378 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL322519 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL322175 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL105661 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2112466 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL108211 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL320071 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL105836 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL105894 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL430658 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL104291 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL105312 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL105690 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL104844 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL104099 | — | Ki | = | 1600.0 | nM | 5.80 |