Assay Detail
Binding
CHEMBL676506
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In vitro binding affinity at human cloned Dopamine receptor D4 expressed in Sf9 cell membranes
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 7.11 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.66 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.75 |
| CHEMBL63576 | — | — | 1 | 7.62 |
| CHEMBL63329 | — | — | 1 | 7.44 |
| CHEMBL422310 | — | — | 1 | 7.43 |
| CHEMBL436274 | — | — | 1 | 7.40 |
| CHEMBL358657 | — | — | 1 | 7.34 |
| CHEMBL148559 | — | — | 1 | 7.32 |
| CHEMBL148752 | — | — | 1 | 7.08 |
| CHEMBL342536 | — | — | 1 | 7.05 |
| CHEMBL146856 | — | — | 1 | 6.96 |
| CHEMBL148353 | — | — | 1 | 6.94 |
| CHEMBL148694 | — | — | 1 | 6.88 |
| CHEMBL148042 | — | — | 1 | 6.79 |
| CHEMBL148965 | — | — | 1 | 6.74 |
| CHEMBL146410 | — | — | 1 | 6.47 |
| CHEMBL356171 | — | — | 1 | 6.45 |
| CHEMBL356149 | — | — | 1 | 6.41 |
| CHEMBL347959 | — | — | 1 | 6.29 |
| CHEMBL424314 | — | — | 1 | - |
| CHEMBL148952 | — | — | 1 | - |
| CHEMBL345964 | — | — | 1 | - |
| CHEMBL357743 | — | — | 1 | - |
| CHEMBL357391 | — | — | 1 | - |
| CHEMBL148836 | — | — | 1 | - |
| CHEMBL147473 | — | — | 1 | - |
| CHEMBL149987 | — | — | 1 | - |
| CHEMBL347292 | — | — | 1 | - |
| CHEMBL357320 | — | — | 1 | - |
| CHEMBL357325 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL42 | CLOZAPINE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL63576 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL63329 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL422310 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL436274 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL358657 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL148559 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL148752 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL342536 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL146856 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL148353 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL148694 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL148042 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL148965 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL146410 | — | Ki | = | 341.0 | nM | 6.47 |
| CHEMBL356171 | — | Ki | = | 356.0 | nM | 6.45 |
| CHEMBL356149 | — | Ki | = | 393.0 | nM | 6.41 |
| CHEMBL347959 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL424314 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL148952 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL345964 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL357743 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL357391 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL148836 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL147473 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL149987 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL347292 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL357320 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL357325 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL355907 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL423760 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL149493 | — | Ki | > | 1000.0 | nM | - |