Assay Detail
Functional
CHEMBL676631
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Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed).
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.03 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10374 | — | — | 1 | 6.41 |
| CHEMBL25438 | PD-156707 SODIUM | — | 1 | 6.38 |
| CHEMBL8981 | PD-156707 | — | 1 | 6.32 |
| CHEMBL10924 | — | — | 1 | 5.94 |
| CHEMBL11115 | — | — | 1 | 5.81 |
| CHEMBL10588 | — | — | 1 | 5.76 |
| CHEMBL267094 | — | — | 1 | 5.57 |
| CHEMBL10648 | — | — | 1 | - |
| CHEMBL10897 | — | — | 1 | - |
| CHEMBL10996 | — | — | 1 | - |
| CHEMBL11162 | — | — | 1 | - |
| CHEMBL10951 | — | — | 1 | - |
| CHEMBL275991 | — | — | 1 | - |
| CHEMBL10733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10374 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL25438 | PD-156707 SODIUM | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL8981 | PD-156707 | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL10924 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL11115 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL10588 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL267094 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL10648 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL10897 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL10996 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL11162 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL10951 | — | IC50 | > | 2700.0 | nM | - |
| CHEMBL275991 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL10733 | — | IC50 | > | 2500.0 | nM | - |