Assay Detail
Binding
CHEMBL676647
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Binding affinity of compound against endothiapepsin
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.75 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266334 | — | — | 1 | 8.19 |
| CHEMBL127208 | — | — | 1 | 7.16 |
| CHEMBL127420 | — | — | 1 | 6.96 |
| CHEMBL328965 | — | — | 1 | 6.62 |
| CHEMBL127931 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266334 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL127208 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL127420 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL328965 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL127931 | — | Ki | = | 16000.0 | nM | 4.80 |