Assay Detail
Binding
CHEMBL676742
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Tested for inhibitory activity against human leukocyte elastase(HLE) enzyme
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Nonpeptidic inhibitors of human leukocyte elastase. 2. Design, synthesis, and in vitro activity of a series of 3-amino-6-arylopyridin-2-one trifluoromethyl ketones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 7.58 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325234 | — | — | 1 | 8.46 |
| CHEMBL112880 | — | — | 1 | 8.42 |
| CHEMBL113132 | — | — | 1 | 8.36 |
| CHEMBL11391 | — | — | 1 | 8.35 |
| CHEMBL113321 | — | — | 1 | 8.25 |
| CHEMBL113261 | — | — | 1 | 8.18 |
| CHEMBL113171 | — | — | 1 | 8.07 |
| CHEMBL418822 | — | — | 1 | 8.04 |
| CHEMBL432961 | — | — | 1 | 7.96 |
| CHEMBL432442 | — | — | 1 | 7.51 |
| CHEMBL325873 | — | — | 1 | 7.50 |
| CHEMBL326616 | — | — | 1 | 7.48 |
| CHEMBL107291 | — | — | 1 | 7.40 |
| CHEMBL322360 | — | — | 1 | 7.38 |
| CHEMBL112971 | — | — | 1 | 7.18 |
| CHEMBL109852 | — | — | 1 | 7.10 |
| CHEMBL13684 | — | — | 1 | 6.55 |
| CHEMBL114024 | — | — | 1 | 6.52 |
| CHEMBL324587 | — | — | 1 | 6.50 |
| CHEMBL109769 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325234 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL112880 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL113132 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL11391 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL113321 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL113261 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL113171 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL418822 | — | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL432961 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL432442 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL325873 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL326616 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL107291 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL322360 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL112971 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL109852 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL13684 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL114024 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL324587 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL109769 | — | Ki | = | 360.0 | nM | 6.44 |