Assay Detail
Binding
CHEMBL676782
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Inhibitory activity against endothelial nitric oxide synthase (eNOS)
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.87 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59925 | — | — | 1 | 7.35 |
| CHEMBL294084 | — | — | 1 | 7.31 |
| CHEMBL40833 | — | — | 1 | 7.14 |
| CHEMBL61427 | — | — | 1 | 7.09 |
| CHEMBL61939 | — | — | 1 | 6.82 |
| CHEMBL294609 | — | — | 1 | 6.82 |
| CHEMBL299677 | — | — | 1 | 6.70 |
| CHEMBL6808 | — | — | 1 | 6.66 |
| CHEMBL62077 | — | — | 1 | 6.64 |
| CHEMBL293022 | — | — | 1 | 6.22 |
| CHEMBL61591 | — | — | 1 | 6.09 |
| CHEMBL302657 | — | — | 1 | 6.00 |
| CHEMBL291544 | — | — | 1 | 5.92 |
| CHEMBL62083 | — | — | 1 | 5.85 |
| CHEMBL60372 | — | — | 1 | 5.72 |
| CHEMBL21619 | 2-AMINOPYRIDINE | — | 1 | 5.55 |
| CHEMBL59592 | — | — | 1 | 5.55 |
| CHEMBL61990 | — | — | 1 | 5.51 |
| CHEMBL292981 | — | — | 1 | 5.48 |
| CHEMBL61599 | — | — | 1 | 5.47 |
| CHEMBL61430 | — | — | 1 | 5.44 |
| CHEMBL7889 | L-NIL | — | 1 | 5.10 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 5.06 |
| CHEMBL60528 | — | — | 1 | 4.78 |
| CHEMBL61139 | — | — | 1 | 4.76 |
| CHEMBL58492 | — | — | 1 | 4.70 |
| CHEMBL59350 | — | — | 1 | 4.62 |
| CHEMBL294044 | — | — | 1 | 4.14 |
| CHEMBL61743 | ISOQUINOLIN-3-AMINE | — | 1 | - |
| CHEMBL61236 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59925 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL294084 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL40833 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL61427 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL61939 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL294609 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL299677 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL6808 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL62077 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL293022 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL61591 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL302657 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL291544 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL62083 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL60372 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL21619 | 2-AMINOPYRIDINE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL59592 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL61990 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL292981 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL61599 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL61430 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL7889 | L-NIL | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL256147 | TILARGININE | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL60528 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL61139 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL58492 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL59350 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL294044 | — | IC50 | = | 72400.0 | nM | 4.14 |
| CHEMBL61743 | ISOQUINOLIN-3-AMINE | IC50 | - | nM | - | |
| CHEMBL61236 | — | IC50 | - | nM | - | |
| CHEMBL299906 | — | IC50 | - | nM | - | |
| CHEMBL292690 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL293728 | — | IC50 | - | nM | - | |
| CHEMBL59235 | — | IC50 | - | nM | - | |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 500000.0 | nM | - |