Assay Detail
Binding
CHEMBL676784
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Inhibitory activity against human endothelial nitric oxide synthase (eNOS)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A new class of selective and potent inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.13 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86810 | — | — | 1 | 6.43 |
| CHEMBL87529 | — | — | 1 | 6.35 |
| CHEMBL87544 | — | — | 1 | 6.16 |
| CHEMBL87186 | — | — | 1 | 6.09 |
| CHEMBL87187 | — | — | 1 | 6.08 |
| CHEMBL40391 | — | — | 1 | 6.05 |
| CHEMBL247378 | 7-NITROINDAZOLE | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86810 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL87529 | — | IC50 | = | 448.0 | nM | 6.35 |
| CHEMBL87544 | — | IC50 | = | 685.0 | nM | 6.16 |
| CHEMBL87186 | — | IC50 | = | 815.0 | nM | 6.09 |
| CHEMBL87187 | — | IC50 | = | 825.0 | nM | 6.08 |
| CHEMBL40391 | — | IC50 | = | 887.0 | nM | 6.05 |
| CHEMBL247378 | 7-NITROINDAZOLE | IC50 | = | 1890.0 | nM | 5.72 |