Assay Detail
Functional
CHEMBL677013
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Inhibition of cellular growth in human adenocarcinoma cell line (GC3/M TK) deficient in thymidine kinase
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GC3/MTK- |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design of thymidylate synthase inhibitors using protein crystal structures: the synthesis and biological evaluation of a novel class of 5-substituted quinazolinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.32 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320775 | NOLATREXED | 3.0 | 1 | 6.00 |
| CHEMBL349723 | — | — | 1 | 5.82 |
| CHEMBL166027 | — | — | 1 | 5.77 |
| CHEMBL162145 | — | — | 1 | 5.69 |
| CHEMBL166369 | — | — | 1 | 5.39 |
| CHEMBL423282 | — | — | 1 | 5.35 |
| CHEMBL350130 | — | — | 1 | 5.30 |
| CHEMBL351606 | — | — | 1 | 5.28 |
| CHEMBL351403 | — | — | 1 | 5.22 |
| CHEMBL163410 | — | — | 1 | 4.82 |
| CHEMBL349969 | — | — | 1 | 4.75 |
| CHEMBL164289 | — | — | 1 | 4.50 |
| CHEMBL351839 | — | — | 1 | - |
| CHEMBL351885 | — | — | 1 | - |
| CHEMBL163411 | — | — | 1 | - |
| CHEMBL164624 | — | — | 1 | - |
| CHEMBL351840 | — | — | 1 | - |
| CHEMBL162498 | — | — | 1 | - |
| CHEMBL164569 | — | — | 1 | - |
| CHEMBL163096 | — | — | 1 | - |
| CHEMBL162613 | — | — | 1 | - |
| CHEMBL165453 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320775 | NOLATREXED | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL349723 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL166027 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL162145 | — | IC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL166369 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL423282 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL350130 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL351606 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL351403 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL163410 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL349969 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL164289 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL351839 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL351885 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL163411 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL164624 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL351840 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL162498 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL164569 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL163096 | — | IC50 | > | 26900.0 | nM | - |
| CHEMBL162613 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL165453 | — | IC50 | > | 50000.0 | nM | - |