Assay Detail
Functional
CHEMBL677014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cellular growth by the MTT colorimetric assay in GC3/M TK-, a human thymidine kinase deficient adenocarcinoma line
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GC3/MTK- |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.57 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9671 | — | — | 1 | 6.68 |
| CHEMBL349878 | — | — | 1 | 6.57 |
| CHEMBL1744235 | — | — | 1 | 6.36 |
| CHEMBL350841 | — | — | 1 | 6.28 |
| CHEMBL9440 | METESIND | 2.0 | 1 | 6.05 |
| CHEMBL348858 | — | — | 1 | 6.04 |
| CHEMBL162592 | — | — | 1 | 6.01 |
| CHEMBL162593 | — | — | 1 | 5.85 |
| CHEMBL161404 | — | — | 1 | 5.82 |
| CHEMBL161053 | — | — | 1 | 5.68 |
| CHEMBL161750 | — | — | 1 | 5.52 |
| CHEMBL422880 | — | — | 1 | 5.48 |
| CHEMBL162411 | — | — | 1 | 5.47 |
| CHEMBL159039 | — | — | 1 | 5.39 |
| CHEMBL275685 | — | — | 1 | 5.34 |
| CHEMBL436435 | — | — | 1 | 5.27 |
| CHEMBL351499 | — | — | 1 | 5.23 |
| CHEMBL161083 | — | — | 1 | 5.16 |
| CHEMBL159155 | — | — | 1 | 5.02 |
| CHEMBL161341 | — | — | 1 | 5.00 |
| CHEMBL9728 | — | — | 1 | 4.80 |
| CHEMBL1788170 | — | — | 1 | 4.60 |
| CHEMBL159072 | — | — | 1 | 4.52 |
| CHEMBL349078 | — | — | 1 | - |
| CHEMBL162539 | — | — | 1 | - |
| CHEMBL161098 | — | — | 1 | - |
| CHEMBL301844 | — | — | 1 | - |
| CHEMBL161325 | — | — | 1 | - |
| CHEMBL161291 | — | — | 1 | - |
| CHEMBL161389 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9671 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL349878 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1744235 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL350841 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL9440 | METESIND | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL348858 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL162592 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL162593 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL161404 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL161053 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL161750 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL422880 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL162411 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL159039 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL275685 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL436435 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL351499 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL161083 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL159155 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL161341 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL9728 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1788170 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL159072 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1744234 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL161173 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL351495 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL158281 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL159050 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL162646 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL159017 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL351601 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL157865 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL350840 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL161453 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL162587 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL161389 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL161291 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL161325 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL301844 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL161098 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL162539 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL349078 | — | IC50 | > | 50000.0 | nM | - |