Assay Detail
Functional
CHEMBL677015
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Inhibitory activity against GC3/M TK- human adreno carcinoma cell lines.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GC3/MTK- |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.47 | 5.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417222 | — | — | 1 | 5.99 |
| CHEMBL159213 | — | — | 1 | 5.92 |
| CHEMBL158542 | — | — | 1 | 5.55 |
| CHEMBL162076 | — | — | 1 | 5.52 |
| CHEMBL161450 | — | — | 1 | 5.48 |
| CHEMBL159364 | — | — | 1 | 5.47 |
| CHEMBL160215 | — | — | 1 | 5.42 |
| CHEMBL162754 | — | — | 1 | 5.41 |
| CHEMBL159209 | — | — | 1 | 5.40 |
| CHEMBL161025 | — | — | 1 | 5.38 |
| CHEMBL161685 | — | — | 1 | 5.37 |
| CHEMBL291548 | — | — | 1 | 5.12 |
| CHEMBL157702 | — | — | 1 | 5.04 |
| CHEMBL159144 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417222 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL159213 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL158542 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL162076 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL161450 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL159364 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL160215 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL162754 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL159209 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL161025 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL161685 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL291548 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL157702 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL159144 | — | IC50 | > | 5000.0 | nM | - |