Assay Detail
Functional
CHEMBL677017
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Inhibition of cellular growth against human adenocarcinoma (GC3/M TK-) deficient in thymidine kinase.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GC3/MTK- |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design of enzyme inhibitors using iterative protein crystallographic analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.46 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25889 | — | — | 1 | 7.31 |
| CHEMBL417222 | — | — | 1 | 5.96 |
| CHEMBL422395 | — | — | 1 | 5.85 |
| CHEMBL299928 | — | — | 1 | 5.82 |
| CHEMBL275685 | — | — | 1 | 5.34 |
| CHEMBL291548 | — | — | 1 | 5.12 |
| CHEMBL56992 | — | — | 1 | 4.80 |
| CHEMBL57002 | — | — | 1 | 4.60 |
| CHEMBL353700 | — | — | 1 | 4.37 |
| CHEMBL57333 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25889 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL417222 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL422395 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL299928 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL275685 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL291548 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL56992 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL57002 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL353700 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL57333 | — | IC50 | > | 10700.0 | nM | - |