Assay Detail
Functional
CHEMBL677018
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Inhibition of GC3/M TK- (human adenocarcinoma) cell growth in vitro.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GC3/MTK- |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.40 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25889 | — | — | 1 | 7.32 |
| CHEMBL417222 | — | — | 1 | 5.75 |
| CHEMBL422395 | — | — | 1 | 5.67 |
| CHEMBL171706 | — | — | 1 | 5.58 |
| CHEMBL162754 | — | — | 1 | 5.41 |
| CHEMBL367651 | — | — | 1 | 5.32 |
| CHEMBL174478 | — | — | 1 | 5.30 |
| CHEMBL172085 | — | — | 1 | 5.28 |
| CHEMBL170573 | — | — | 1 | 5.28 |
| CHEMBL171418 | — | — | 1 | 5.21 |
| CHEMBL353951 | — | — | 1 | 5.17 |
| CHEMBL291548 | — | — | 1 | 5.12 |
| CHEMBL170527 | — | — | 1 | 4.83 |
| CHEMBL171189 | — | — | 1 | 4.31 |
| CHEMBL173683 | — | — | 1 | - |
| CHEMBL171754 | — | — | 1 | - |
| CHEMBL57333 | — | — | 1 | - |
| CHEMBL170204 | — | — | 1 | - |
| CHEMBL301423 | — | — | 1 | - |
| CHEMBL171641 | — | — | 1 | - |
| CHEMBL172033 | — | — | 1 | - |
| CHEMBL355011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25889 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL417222 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL422395 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL171706 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL162754 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL367651 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL174478 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL172085 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL170573 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL171418 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL353951 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL291548 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL170527 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL171189 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL173683 | — | IC50 | > | 26000.0 | nM | - |
| CHEMBL171754 | — | IC50 | > | 77000.0 | nM | - |
| CHEMBL57333 | — | IC50 | > | 10700.0 | nM | - |
| CHEMBL170204 | — | IC50 | > | 5300.0 | nM | - |
| CHEMBL301423 | — | IC50 | > | 4300.0 | nM | - |
| CHEMBL171641 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL172033 | — | IC50 | > | 4000.0 | nM | - |
| CHEMBL355011 | — | IC50 | > | 54000.0 | nM | - |