Assay Detail
Functional
CHEMBL677020
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Activity for growth inhibition in tissue culture of thymidine kinase-deficient human adenocarcinoma cell line (GC3/M TK-)value in parenthesis indicates % inhibition
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GC3/MTK- |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.39 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170177 | — | — | 1 | 5.56 |
| CHEMBL172474 | — | — | 1 | 5.30 |
| CHEMBL171549 | — | — | 1 | 5.30 |
| CHEMBL177208 | — | — | 1 | - |
| CHEMBL433923 | — | — | 1 | - |
| CHEMBL170767 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170177 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL172474 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL171549 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL177208 | — | IC50 | > | 5600.0 | nM | - |
| CHEMBL433923 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL170767 | — | IC50 | > | 5000.0 | nM | - |