Assay Detail
Binding
CHEMBL677099
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]17-beta-estradiol from Estrogen receptor of rabbit uterine tissue
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel thio-substituted chromanes as high-affinity partial agonists for the estrogen receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.14 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 9.30 |
| CHEMBL299942 | — | — | 1 | 8.51 |
| CHEMBL554789 | — | — | 1 | 8.19 |
| CHEMBL6318 | IDOXIFENE | 2.0 | 1 | 8.12 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 8.11 |
| CHEMBL52598 | — | — | 1 | 8.01 |
| CHEMBL417596 | — | — | 1 | 7.72 |
| CHEMBL301327 | LEVORMELOXIFENE | 2.0 | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL299942 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL554789 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL6318 | IDOXIFENE | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL52598 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL417596 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL301327 | LEVORMELOXIFENE | IC50 | = | 73.0 | nM | 7.14 |