Assay Detail
Binding
CHEMBL677101
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Binding affinity for estrogen receptor of rabbit uterine skeletal muscle tissue
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and pharmacology of a novel pyrrolo[2,1,5-cd] indolizine (NNC 45-0095), a high affinity non-steroidal agonist for the estrogen receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.59 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 9.15 |
| CHEMBL1628161 | MOXESTROL | 2.0 | 1 | 8.60 |
| CHEMBL420017 | — | — | 1 | 8.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1628161 | MOXESTROL | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL420017 | — | IC50 | = | 9.5 | nM | 8.02 |