Assay Detail
Binding
CHEMBL677160
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Displacement of [3H]-estradiol from estrogen receptor (ER)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Phenolic metabolites of clomiphene: [(E,Z)-2-[4-(1,2-diphenyl-2-chlorovinyl)phenoxy]ethyl]diethylamine. Preparation, electrophilicity, and effects in MCF 7 breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.72 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.52 |
| CHEMBL955 | 3'-METHOXY-4'HYDROXYCLOMIPHENE | — | 1 | 6.11 |
| CHEMBL292185 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135 | ESTRADIOL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL955 | 3'-METHOXY-4'HYDROXYCLOMIPHENE | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL292185 | — | IC50 | = | 3000.0 | nM | 5.52 |