Assay Detail
Functional
CHEMBL677166
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against normal fibroblast MRHF cell line
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MRHF |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.94 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL147506 | — | — | 1 | 5.52 |
| CHEMBL98669 | — | — | 1 | 5.30 |
| CHEMBL317814 | — | — | 1 | 4.96 |
| CHEMBL346414 | — | — | 1 | 4.47 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 4.44 |
| CHEMBL148968 | — | — | 1 | - |
| CHEMBL353629 | — | — | 1 | - |
| CHEMBL148313 | — | — | 1 | - |
| CHEMBL168668 | — | — | 1 | - |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | - |
| CHEMBL149444 | — | — | 1 | - |
| CHEMBL149172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL147506 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL98669 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL317814 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL346414 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL148968 | — | IC50 | > | 37000.0 | nM | - |
| CHEMBL353629 | — | IC50 | > | 37000.0 | nM | - |
| CHEMBL148313 | — | IC50 | > | 37000.0 | nM | - |
| CHEMBL168668 | — | IC50 | > | 36000.0 | nM | - |
| CHEMBL27759 | ENTINOSTAT | IC50 | > | 37000.0 | nM | - |
| CHEMBL149444 | — | IC50 | > | 37000.0 | nM | - |
| CHEMBL149172 | — | IC50 | > | 25000.0 | nM | - |