Assay Detail
Binding
CHEMBL677269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit specific binding of [125I]- -ET-1 to human GH cells which express endothelin B receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | GH |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective ET-A antagonists. 1. Syntheses and structure-activity relationships of N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.24 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175616 | BOSENTAN SODIUM | — | 1 | 6.51 |
| CHEMBL115951 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175616 | BOSENTAN SODIUM | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL115951 | — | IC50 | = | 1100.0 | nM | 5.96 |