Assay Detail
Binding
CHEMBL677270
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Ability to inhibit specific binding of [125I]- -ET-1 to human GH cells which express endothelin B receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | GH |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent and selective ET-A antagonists. 2. Discovery and evaluation of potent and water soluble N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.67 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1627022 | — | — | 1 | 8.08 |
| CHEMBL1627023 | — | — | 1 | 7.51 |
| CHEMBL112531 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1627022 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL1627023 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL112531 | — | IC50 | = | 38.0 | nM | 7.42 |