Assay Detail
Binding
CHEMBL677437
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Inhibition of human neutrophil elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNa
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Peptidyl alpha-ketoheterocyclic inhibitors of human neutrophil elastase. 3. In vitro and in vivo potency of a series of peptidyl alpha-ketobenzoxazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 9.11 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339307 | — | — | 1 | 10.22 |
| CHEMBL405664 | — | — | 1 | 10.00 |
| CHEMBL334978 | — | — | 1 | 9.74 |
| CHEMBL336779 | — | — | 1 | 9.70 |
| CHEMBL419985 | — | — | 1 | 9.70 |
| CHEMBL130966 | — | — | 1 | 9.52 |
| CHEMBL127714 | — | — | 1 | 9.48 |
| CHEMBL262516 | — | — | 1 | 9.47 |
| CHEMBL337931 | — | — | 1 | 9.46 |
| CHEMBL111029 | — | — | 1 | 9.43 |
| CHEMBL339650 | — | — | 1 | 9.37 |
| CHEMBL127615 | — | — | 1 | 9.30 |
| CHEMBL340818 | — | — | 1 | 9.30 |
| CHEMBL273818 | — | — | 1 | 9.26 |
| CHEMBL128499 | — | — | 1 | 9.22 |
| CHEMBL419800 | — | — | 1 | 9.19 |
| CHEMBL337968 | — | — | 1 | 9.18 |
| CHEMBL127780 | — | — | 1 | 9.18 |
| CHEMBL128553 | — | — | 1 | 9.09 |
| CHEMBL131580 | — | — | 1 | 9.00 |
| CHEMBL335233 | — | — | 1 | 8.96 |
| CHEMBL128415 | — | — | 1 | 8.96 |
| CHEMBL406200 | — | — | 1 | 8.89 |
| CHEMBL130002 | — | — | 1 | 8.82 |
| CHEMBL340627 | — | — | 1 | 8.74 |
| CHEMBL129496 | — | — | 1 | 8.72 |
| CHEMBL338651 | — | — | 1 | 8.64 |
| CHEMBL131107 | — | — | 1 | 8.62 |
| CHEMBL108783 | — | — | 1 | 8.52 |
| CHEMBL1237168 | — | — | 1 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339307 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL405664 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL334978 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL336779 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL419985 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL130966 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL127714 | — | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL262516 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL337931 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL111029 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL339650 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL127615 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL340818 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL273818 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL128499 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL419800 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL337968 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL127780 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL128553 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL131580 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL335233 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL128415 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL406200 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL130002 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL340627 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL129496 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL338651 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL131107 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL108783 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1237168 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL435413 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL336132 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL128410 | — | Ki | = | 11.0 | nM | 7.96 |