Assay Detail
Binding
CHEMBL677456
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Binding affinity towards human dopamine D4 receptor was determined via standard competitive displacement assays using [3H]-YM 09151 as radioligand
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 49 | 7.58 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104716 | — | — | 1 | 8.70 |
| CHEMBL104497 | — | — | 1 | 8.70 |
| CHEMBL107742 | — | — | 1 | 8.52 |
| CHEMBL108157 | — | — | 1 | 8.52 |
| CHEMBL104273 | — | — | 1 | 8.52 |
| CHEMBL104832 | — | — | 1 | 8.40 |
| CHEMBL104788 | — | — | 1 | 8.40 |
| CHEMBL106208 | — | — | 1 | 8.30 |
| CHEMBL105011 | — | — | 1 | 8.30 |
| CHEMBL419908 | — | — | 1 | 8.22 |
| CHEMBL419356 | — | — | 1 | 8.22 |
| CHEMBL321538 | — | — | 1 | 8.22 |
| CHEMBL104719 | — | — | 1 | 8.15 |
| CHEMBL104614 | — | — | 1 | 8.15 |
| CHEMBL104800 | — | — | 1 | 8.15 |
| CHEMBL104256 | — | — | 1 | 8.15 |
| CHEMBL322326 | — | — | 1 | 8.10 |
| CHEMBL105304 | — | — | 1 | 8.10 |
| CHEMBL104579 | — | — | 1 | 8.00 |
| CHEMBL104321 | — | — | 1 | 7.96 |
| CHEMBL419916 | — | — | 1 | 7.92 |
| CHEMBL320440 | — | — | 1 | 7.92 |
| CHEMBL107804 | — | — | 1 | 7.92 |
| CHEMBL104380 | — | — | 1 | 7.89 |
| CHEMBL104238 | — | — | 1 | 7.85 |
| CHEMBL104399 | — | — | 1 | 7.85 |
| CHEMBL107020 | — | — | 1 | 7.82 |
| CHEMBL323525 | — | — | 1 | 7.82 |
| CHEMBL326202 | — | — | 1 | 7.68 |
| CHEMBL321734 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104716 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL104497 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL108157 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL104273 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL107742 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL104832 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL104788 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL106208 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL105011 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL419908 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL419356 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL321538 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL104800 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL104719 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL104614 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL104256 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL322326 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL105304 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL104579 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL104321 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL419916 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL320440 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL107804 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL104380 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL104238 | — | Ki | = | 14.2 | nM | 7.85 |
| CHEMBL104399 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL107020 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL323525 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL326202 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL321734 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL106914 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL104155 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL106007 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL106751 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL104063 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL323022 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL322567 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL324867 | — | Ki | = | 281.0 | nM | 6.55 |
| CHEMBL107351 | — | Ki | = | 335.0 | nM | 6.47 |
| CHEMBL108261 | — | Ki | = | 522.0 | nM | 6.28 |
| CHEMBL104498 | — | Ki | = | 726.0 | nM | 6.14 |
| CHEMBL104138 | — | Ki | = | 1361.0 | nM | 5.87 |
| CHEMBL104514 | — | Ki | = | 3854.0 | nM | 5.41 |
| CHEMBL431437 | — | Ki | = | 5745.0 | nM | 5.24 |
| CHEMBL106170 | — | Ki | = | 7264.0 | nM | 5.14 |
| CHEMBL104756 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL419911 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL104299 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL42 | CLOZAPINE | Ki | = | 9.0 | nM | - |