Assay Detail
Binding
CHEMBL677459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human dopamine transporter
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
From hit to lead. Analyzing structure-profile relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.95 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116463 | — | — | 1 | 6.11 |
| CHEMBL117537 | — | — | 1 | 6.02 |
| CHEMBL326263 | — | — | 1 | 6.00 |
| CHEMBL113956 | — | — | 1 | 6.00 |
| CHEMBL116735 | — | — | 1 | 5.89 |
| CHEMBL325945 | — | — | 1 | 5.82 |
| CHEMBL325516 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116463 | — | IC50 | = | 781.0 | nM | 6.11 |
| CHEMBL117537 | — | IC50 | = | 954.0 | nM | 6.02 |
| CHEMBL326263 | — | IC50 | = | 996.0 | nM | 6.00 |
| CHEMBL113956 | — | IC50 | = | 994.0 | nM | 6.00 |
| CHEMBL116735 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL325945 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL325516 | — | IC50 | = | 1650.0 | nM | 5.78 |