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Assay Detail

CHEMBL677475

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against endothelial nitric oxide synthase (eNOS)
37
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Nitric oxide synthase 3 (CHEMBL4802)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.
Gómez-Vidal JA, Martásek P, Roman LJ, Silverman RB.
J Med Chem (2004) 47 : 703 -710
PubMed 14736250 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 37 4.62 6.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL419740 2 6.32
CHEMBL1169419 1 3.12
CHEMBL161297 1 3.06
CHEMBL1169428 2 -
CHEMBL163811 1 -
CHEMBL2368271 1 -
CHEMBL2368265 1 -
CHEMBL1169424 2 -
CHEMBL1169433 2 -
CHEMBL1169426 1 -
CHEMBL1169430 2 -
CHEMBL1169429 2 -
CHEMBL161697 1 -
CHEMBL2368266 1 -
CHEMBL1169434 1 -
CHEMBL1169423 2 -
CHEMBL1169415 1 -
CHEMBL1169420 1 -
CHEMBL348164 1 -
CHEMBL163165 1 -
CHEMBL1169425 1 -
CHEMBL2368268 1 -
CHEMBL2368283 1 -
CHEMBL348768 1 -
CHEMBL1169427 1 -
CHEMBL1169416 1 -
CHEMBL352160 1 -
CHEMBL1169421 1 -
CHEMBL1169422 1 -
CHEMBL1169417 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL419740 IC50 = 480.0 nM 6.32
CHEMBL419740 IC50 = 1100.0 nM 5.96
CHEMBL1169419 IC50 = 760000.0 nM 3.12
CHEMBL161297 IC50 = 880000.0 nM 3.06
CHEMBL1169428 IC50 > 100000.0 nM -
CHEMBL1169415 IC50 > 100000.0 nM -
CHEMBL163811 IC50 > 100000.0 nM -
CHEMBL2368271 IC50 > 100000.0 nM -
CHEMBL1169423 IC50 > 100000.0 nM -
CHEMBL2368265 IC50 > 100000.0 nM -
CHEMBL1169424 IC50 > 100000.0 nM -
CHEMBL1169433 IC50 > 100000.0 nM -
CHEMBL1169426 IC50 > 100000.0 nM -
CHEMBL1169430 IC50 > 100000.0 nM -
CHEMBL1169430 IC50 > 100000.0 nM -
CHEMBL1169429 IC50 > 100000.0 nM -
CHEMBL161697 IC50 > 100000.0 nM -
CHEMBL2368266 IC50 > 100000.0 nM -
CHEMBL1169434 IC50 > 100000.0 nM -
CHEMBL1169423 IC50 > 100000.0 nM -
CHEMBL1169424 IC50 > 100000.0 nM -
CHEMBL1169428 IC50 > 100000.0 nM -
CHEMBL1169429 IC50 > 100000.0 nM -
CHEMBL1169420 IC50 > 100000.0 nM -
CHEMBL348164 IC50 > 100000.0 nM -
CHEMBL163165 IC50 > 100000.0 nM -
CHEMBL1169425 IC50 > 100000.0 nM -
CHEMBL2368268 IC50 > 100000.0 nM -
CHEMBL1169417 IC50 > 100000.0 nM -
CHEMBL1169433 IC50 > 100000.0 nM -
CHEMBL2368283 IC50 > 100000.0 nM -
CHEMBL348768 IC50 > 100000.0 nM -
CHEMBL1169427 IC50 > 100000.0 nM -
CHEMBL1169416 IC50 > 100000.0 nM -
CHEMBL352160 IC50 > 100000.0 nM -
CHEMBL1169421 IC50 > 100000.0 nM -
CHEMBL1169422 IC50 > 100000.0 nM -