Assay Detail
Binding
CHEMBL677601
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Human Neutrophil Elastase-catalyzed hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-p- nitroanilide.
39
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonpeptidic inhibitors of human neutrophil elastase. 7. Design, synthesis, and in vitro activity of a series of pyridopyrimidine trifluoromethyl ketones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 39 | 7.34 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL276307 | — | — | 1 | 9.02 |
| CHEMBL354883 | — | — | 1 | 8.80 |
| CHEMBL13753 | — | — | 1 | 8.55 |
| CHEMBL11391 | — | — | 2 | 8.35 |
| CHEMBL14121 | — | — | 1 | 8.24 |
| CHEMBL14165 | — | — | 1 | 8.12 |
| CHEMBL275043 | — | — | 1 | 8.10 |
| CHEMBL14293 | — | — | 1 | 8.08 |
| CHEMBL275340 | — | — | 1 | 8.00 |
| CHEMBL14115 | — | — | 1 | 8.00 |
| CHEMBL13902 | — | — | 1 | 7.92 |
| CHEMBL13954 | — | — | 1 | 7.82 |
| CHEMBL13863 | — | — | 1 | 7.82 |
| CHEMBL14631 | — | — | 1 | 7.80 |
| CHEMBL278222 | — | — | 1 | 7.80 |
| CHEMBL278912 | — | — | 1 | 7.72 |
| CHEMBL273486 | — | — | 1 | 7.68 |
| CHEMBL268005 | — | — | 1 | 7.66 |
| CHEMBL14177 | — | — | 1 | 7.58 |
| CHEMBL14064 | — | — | 1 | 7.38 |
| CHEMBL13740 | — | — | 1 | 7.36 |
| CHEMBL13923 | — | — | 1 | 7.21 |
| CHEMBL14222 | — | — | 1 | 7.13 |
| CHEMBL416159 | — | — | 1 | 7.00 |
| CHEMBL13937 | — | — | 1 | 6.80 |
| CHEMBL276181 | — | — | 1 | 6.64 |
| CHEMBL13684 | — | — | 2 | 6.55 |
| CHEMBL14176 | — | — | 1 | 6.54 |
| CHEMBL13804 | — | — | 1 | 6.51 |
| CHEMBL269448 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL276307 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL354883 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL13753 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL11391 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL11391 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL14121 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL14165 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL275043 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL14293 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL14115 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL275340 | — | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL13902 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL13863 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL13954 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL14631 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL278222 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL278912 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL273486 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL268005 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL14177 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL14064 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL13740 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL13923 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL14222 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL416159 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL13937 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL276181 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL13684 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL13684 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL14176 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL13804 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL269448 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL14516 | — | Ki | = | 469.0 | nM | 6.33 |
| CHEMBL14128 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL267800 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL273612 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL276182 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL275723 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL14223 | — | Ki | = | 2700.0 | nM | 5.57 |